2025-09-26 Hacker News Top Articles and Its Summaries
1. SimpleFold: Folding proteins is simpler than you think Total comment counts : 19 Summary SimpleFold is a flow-matching-based protein folding model that uses only general transformer layers, avoiding expensive modules like triangle attention or pair biases. Trained with a generative flow-matching objective, it scales to 3B parameters and learns from over 8.6 million distilled structures plus experimental PDB data, making it the largest-scale folding model to date. It achieves competitive performance on standard benchmarks and strong ensemble predictions, challenging the idea that domain-specific architectures are required....